Depending on the way the tree was populated, the sender and the e.Source values may vary.

One of the possible solutions is to use e.OriginalSource and find TreeViewItem using the VisualTreeHelper:

private void OnPreviewMouseRightButtonDown(object sender, MouseButtonEventArgs e)
{
    TreeViewItem treeViewItem = VisualUpwardSearch(e.OriginalSource as DependencyObject);

    if (treeViewItem != null)
    {
        treeViewItem.Focus();
        e.Handled = true;
    }
}

static TreeViewItem VisualUpwardSearch(DependencyObject source)
{
    while (source != null && !(source is TreeViewItem))
        source = VisualTreeHelper.GetParent(source);

    return source as TreeViewItem;
}