You can use the drop_duplicates method to get the unique rows in a DataFrame:

In [29]: df = pd.DataFrame({'a':[1,2,1,2], 'b':[3,4,3,5]})

In [30]: df
Out[30]:
   a  b
0  1  3
1  2  4
2  1  3
3  2  5

In [32]: df.drop_duplicates()
Out[32]:
   a  b
0  1  3
1  2  4
3  2  5

You can also provide the subset keyword argument if you only want to use certain columns to determine uniqueness. See the docstring.