If you use the matplotlib object-oriented approach, this is a simple task using ax.set_xticklabels() and ax.set_yticklabels():

import matplotlib.pyplot as plt

# Create Figure and Axes instances
fig,ax = plt.subplots(1)

# Make your plot, set your axes labels
ax.plot(sim_1['t'],sim_1['V'],'k')
ax.set_ylabel('V')
ax.set_xlabel('t')

# Turn off tick labels
ax.set_yticklabels([])
ax.set_xticklabels([])

plt.show()