Try deleting the virtualenv you created. Then create a new virtualenv with:

virtualenv flask

Then:

cd flask

Now let's activate the virtualenv:

source bin/activate

Now you should see (flask) on the left of the command line.

Let's install flask:

pip install flask

Then create a file named hello.py (NOTE: see UPDATE Flask 1.0.2 below):

from flask import Flask
app = Flask(__name__)

@app.route("/")
def hello():
    return "Hello World!"

if __name__ == "__main__":
    app.run()

and run it with:

python hello.py

UPDATE Flask 1.0.2

With the new flask release there is no need to run the app from your script. hello.py should look like this now:

from flask import Flask
app = Flask(__name__)

@app.route("/")
def hello():
    return "Hello World!"

and run it with:

FLASK_APP=hello.py flask run

Make sure to be inside the folder where hello.py is when running the latest command.

All the steps before the creation of the hello.py apply for this case as well