I use a minor mode for all my "override" key bindings:

(defvar my-keys-minor-mode-map
  (let ((map (make-sparse-keymap)))
    (define-key map (kbd "C-i") 'some-function)
  "my-keys-minor-mode keymap.")

(define-minor-mode my-keys-minor-mode
  "A minor mode so that my key settings override annoying major modes."
  :init-value t
  :lighter " my-keys")

(my-keys-minor-mode 1)

This has the added benefit of being able to turn off all my modifications in one fell swoop (just disable the minor mode) in case someone else is driving the keyboard or if I need to see what a default key binding does.

Note that you may need to turn this off in the minibuffer:

(defun my-minibuffer-setup-hook ()
  (my-keys-minor-mode 0))

(add-hook 'minibuffer-setup-hook 'my-minibuffer-setup-hook)