str = str.replace(/abc/g, '');

In response to comment:

var find = 'abc';
var re = new RegExp(find, 'g');

str = str.replace(re, '');

In response to Click Upvote's comment, you could simplify it even more:

function replaceAll(str, find, replace) {
  return str.replace(new RegExp(find, 'g'), replace);

Note: Regular expressions contain special (meta) characters, and as such it is dangerous to blindly pass an argument in the find function above without pre-processing it to escape those characters. This is covered in the Mozilla Developer Network's JavaScript Guide on Regular Expressions, where they present the following utility function (which has changed at least twice since this answer was originally written, so make sure to check the MDN site for potential updates):

function escapeRegExp(string) {
  return string.replace(/[.*+\-?^${}()|[\]\\]/g, '\\$&'); // $& means the whole matched string

So in order to make the replaceAll() function above safer, it could be modified to the following if you also include escapeRegExp:

function replaceAll(str, find, replace) {
  return str.replace(new RegExp(escapeRegExp(find), 'g'), replace);