Yep. For OSX, open Terminal and run:

$ open -a Google\ Chrome --args --disable-web-security --user-data-dir

--user-data-dir required on Chrome 49+ on OSX

For Linux run:

$ google-chrome --disable-web-security

Also if you're trying to access local files for dev purposes like AJAX or JSON, you can use this flag too.


For Windows go into the command prompt and go into the folder where Chrome.exe is and type

chrome.exe --disable-web-security

That should disable the same origin policy and allow you to access local files.

Update: For Chrome 22+ you will be presented with an error message that says:

You are using an unsupported command-line flag: --disable-web-security. Stability and security will suffer.

However you can just ignore that message while developing.