You can override the serializer __init__ method and set the fields attribute dynamically, based on the query params. You can access the request object throughout the context, passed to the serializer.

Here is a copy&paste from Django Rest Framework documentation example on the matter:

from rest_framework import serializers

class DynamicFieldsModelSerializer(serializers.ModelSerializer):
    A ModelSerializer that takes an additional `fields` argument that
    controls which fields should be displayed.

    def __init__(self, *args, **kwargs):
        # Instantiate the superclass normally
        super(DynamicFieldsModelSerializer, self).__init__(*args, **kwargs)

        fields = self.context['request'].query_params.get('fields')
        if fields:
            fields = fields.split(',')
            # Drop any fields that are not specified in the `fields` argument.
            allowed = set(fields)
            existing = set(self.fields.keys())
            for field_name in existing - allowed:

class UserSerializer(DynamicFieldsModelSerializer, serializers.HyperlinkedModelSerializer):

    class Meta:
        model = User
        fields = ('url', 'username', 'email')