You could use the String.IndexOf Method and pass StringComparison.OrdinalIgnoreCase as the type of search to use:

string title = "STRING";
bool contains = title.IndexOf("string", StringComparison.OrdinalIgnoreCase) >= 0;

Even better is defining a new extension method for string:

public static class StringExtensions
{
    public static bool Contains(this string source, string toCheck, StringComparison comp)
    {
        return source?.IndexOf(toCheck, comp) >= 0;
    }
}

Note, that null propagation ?. is available since C# 6.0 (VS 2015), for older versions use

if (source == null) return false;
return source.IndexOf(toCheck, comp) >= 0;

USAGE:

string title = "STRING";
bool contains = title.Contains("string", StringComparison.OrdinalIgnoreCase);