In general, anything that spans all the way across a screen is difficult for users to read. I'm not entirely sure if I understand the content you will have on this page, but assuming that what is shown would be all of the content, I would recommend making the profile box into a left sidebar and aligning the "about" text in the remaining 2/3rds (or so) of the screen, like this:


download bmml source – Wireframes created with Balsamiq Mockups

This would also allow more room for longer "about" info, since yours would clip longer text and force users to scroll.

If there would not be enough content to fill a layout like this, then maybe you could use your layout but in a skinnier page with wider side margins, which would make it look better proportionally. Of course, this would not be a solution if there are other pages to this site that would with the wider layout.